Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977606 | 0.86 | CHEK2 (0.38) | GCGRKDM4EMAPTKMT2A | |
| SCHEMBL7977895 | 0.83 | SIRT2 (0.61) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7977742 | 0.82 | PRKD3 (0.49) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7991809 | 0.81 | SIRT2 (0.59) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7989667 | 0.81 | SIRT2 (0.61) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7989520 | 0.80 | SLC2A1 (0.51) | SIRT2SIRT1SIRT3TARBP2TP53 | |
| SCHEMBL7977730 | 0.80 | SIRT2 (0.50) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7991536 | 0.79 | SIRT2 (0.52) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7989731 | 0.79 | SIRT2 (0.49) | SIRT2SIRT1SIRT3TARBP2GABRA2 | |
| SCHEMBL7977723 | 0.78 | SIRT2 (0.48) | SIRT2SIRT1SIRT3TARBP2GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |