Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549333 | 0.90 | KDR (0.43) | KDRFLT1FLT4HCRTR1HCRTR2 | |
| SCHEMBL7546645 | 0.89 | FLT1 (0.40) | KDRFLT1FLT4FYNHTR6 | |
| SCHEMBL7546769 | 0.87 | KDR (0.51) | KDRFLT1FLT4PDE4BFYN | |
| SCHEMBL7549222 | 0.86 | KDR (0.40) | KDRFLT1FLT4HTR6ALPL | |
| SCHEMBL7549609 | 0.85 | KDR (0.49) | KDRFLT1FLT4GRIN2BKMT2A | |
| SCHEMBL7990227 | 0.84 | PDE4B (0.45) | KDRFLT1FLT4PDE4BPDE4D | |
| SCHEMBL7990501 | 0.84 | KDR (0.58) | KDRFLT1FLT4ALPLCNR2 | |
| SCHEMBL7994139 | 0.83 | KDR (0.41) | KDRFLT1FLT4PDE4BPDE4D | |
| SCHEMBL7988607 | 0.83 | KDR (0.43) | KDRFLT1FLT4GRIN2BTAAR1 | |
| SCHEMBL7994193 | 0.81 | KDR (0.49) | KDRFLT1FLT4PDE4BFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |