Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990119 | 1.00 | NR1H4 (0.45) | NR1H4KMT2AMEN1ALDH1A1GRIN1 | |
| SCHEMBL6787162 | 0.86 | NR1H4 (0.48) | NR1H4KMT2AMEN1ALDH1A1GRIN1 | |
| SCHEMBL6196704 | 0.83 | MAPT (0.39) | KMT2AMEN1LMNAMAPTCYP1A2 | |
| SCHEMBL6786973 | 0.83 | MAPT (0.39) | KMT2AMEN1LMNAMAPTCYP1A2 | |
| SCHEMBL6198499 | 0.79 | MAPT (0.37) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL6198492 | 0.79 | MAPT (0.37) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL6643040 | 0.78 | NR1H4 (0.47) | NR1H4KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6643038 | 0.78 | NR1H4 (0.47) | NR1H4KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL13826359 | 0.74 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL11452074 | 0.72 | KMT2A (0.77) | NR1H4KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228861-B1 | BENIGN PROSTATIC HYPERPLASIA; ANTICHOLESTEROL AGENTS; IMPOTENCY; INTRAOCULAR PRESSURE; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-05-08 | — | — | US | disclosed |
| EP-0866708-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0866708-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997017969-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |