SCHEMBL7990256

SCHEMBL7990256

COc1ccc(C)cc1/C=C/C[C@@H](C)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.42
ALDH1A1 P00352 3/20 0.39
CYP3A4 P08684 1/20 0.39
MEN1 O00255 2/20 0.38
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 1/20 0.38
CYP1A1 P04798 3/20 0.37
CYP1B1 Q16678 3/20 0.37
CYP1A2 P05177 1/20 0.37
NFE2L2 Q16236 1/20 0.37
L3MBTL4 Q8NA19 1/20 0.36
L3MBTL3 Q96JM7 1/20 0.36
BACE1 P56817 1/20 0.36
POLB P06746 2/20 0.35
KDM4E B2RXH2 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
GRIK1 P39086 1/20 0.35
GRIK2 Q13002 1/20 0.35
GRIK3 Q13003 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7990251 1.00 ACHE (0.42) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7999283 0.85 ACHE (0.40) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL8002228 0.85 ACHE (0.40) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL8000069 0.83 PDE5A (0.38) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7990986 0.83 PDE5A (0.38) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7991168 0.83 PDE5A (0.38) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7990406 0.82 ACHE (0.40) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7990557 0.82 ACHE (0.40) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7992739 0.82 PDE5A (0.37) ACHEALDH1A1CYP3A4MEN1MAPT
SCHEMBL7990165 0.82 PDE5A (0.37) ACHEALDH1A1CYP3A4MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009117594-A1 FLUORINATED MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2009-09-24 WO disclosed