Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424448 | 0.82 | CCNE2 (0.54) | PRKCAGSK3BCCNE2CDK4CCND1 | |
| SCHEMBL7651446 | 0.81 | CCNE2 (0.47) | PRKCAGSK3BCCNE2CDK4CCND1 | |
| SCHEMBL6952810 | 0.81 | CCNT1 (0.37) | PRKCAGSK3BCDK2 | |
| Enmd-981693 SCHEMBL608128 | 0.77 | CCNE2 (0.69) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| Enmd-981693 SCHEMBL29350364 | 0.77 | CCNE2 (0.69) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6956474 | 0.75 | ASAH1 (0.38) | CDK2 | |
| SCHEMBL668748 | 0.74 | CCNE2 (0.57) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL6427037 | 0.74 | CCNE2 (0.57) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7497269 | 0.74 | CTSV (0.51) | PRKCAGSK3BCCNE2CDK4CCND1 | |
| SCHEMBL6425702 | 0.74 | CCNE2 (0.54) | CCNE2CDK4CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313143-B1 | USEFUL IN THERAPY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |