Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 19/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064820 | 0.90 | ADORA2B (0.52) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064586 | 0.90 | ADORA2B (0.49) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064462 | 0.89 | ADORA2B (0.49) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL798903 | 0.88 | ADORA2B (0.48) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL797622 | 0.88 | ADORA2B (0.48) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL1724513 | 0.86 | ADORA2B (0.55) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL30891873 | 0.86 | ADORA2B (0.46) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064643 | 0.84 | ADORA2B (0.45) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064897 | 0.79 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064592 | 0.79 | ADORA2B (0.54) | ADORA2BADORA2AADORA1ADORA3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616470-A1 | PURINE COMPOUNDS AS PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS, THEIR PROCESS AND MEDICINAL APPLICATIONS | Advinus Therapeutics Limited (IN) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035548-A1 | PURINE COMPOUNDS AS PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS, THEIR PROCESS AND MEDICINAL APPLICATIONS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2012-03-22 | — | — | WO | claimed |