Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 9/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990552 | 1.00 | LTB4R (0.57) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7990555 | 1.00 | LTB4R (0.57) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7990747 | 0.89 | LTB4R (0.56) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7990750 | 0.89 | LTB4R (0.56) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7990752 | 0.89 | LTB4R (0.56) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7987688 | 0.81 | LTB4R (0.47) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7987682 | 0.81 | LTB4R (0.47) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7987685 | 0.81 | LTB4R (0.47) | LTB4RLTB4R2PDE4DMAPTMEN1 | |
| SCHEMBL7976808 | 0.75 | LTB4R (0.82) | LTB4RLTB4R2 | |
| SCHEMBL7990963 | 0.75 | LTB4R (0.76) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |