SCHEMBL7990621

SCHEMBL7990621

N#Cc1cnc(OCc2ccccc2)c(O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.51
GABRG2 P18507 2/20 0.48
GABRB3 P28472 2/20 0.48
GABRA5 P31644 2/20 0.48
GABRA3 P34903 2/20 0.48
SQOR Q9Y6N5 1/20 0.47
LRRK2 Q5S007 1/20 0.44
LMNA P02545 2/20 0.44
CYP1A2 P05177 1/20 0.44
PTGS1 P23219 1/20 0.44
SLC6A2 P23975 1/20 0.44
CYP2C19 P33261 1/20 0.44
PTGS2 P35354 1/20 0.44
SLC6A3 Q01959 1/20 0.44
HIF1A Q16665 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7990438 0.79 EGLN1 (0.36) GABRG2GABRB3GABRA5GABRA3EGLN2
SCHEMBL214965 0.76 MAOB (0.58) MAOBGABRG2GABRB3GABRA5GABRA3
SCHEMBL12458014 0.73 MAOB (0.63) MAOBGABRG2GABRB3GABRA5GABRA3
SCHEMBL7994013 0.72 MAOB (0.54) MAOBLMNACYP2C19ALDH1A1HPGD
SCHEMBL1221481 0.72 MAOB (0.62) MAOBGABRG2GABRB3GABRA5GABRA3
SCHEMBL214243 0.71 MAOB (0.65) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL2735788 0.71 MAOB (0.76) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL9479980 0.71 MAOB (0.51) MAOBGABRG2GABRB3GABRA5GABRA3
SCHEMBL21408266 0.71 MAOB (0.50) MAOBGABRG2GABRB3GABRA5GABRA3
SCHEMBL17316167 0.70 HPGDS (0.62) MAOBGABRG2GABRB3GABRA5GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291530-B1 Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity NOVARTIS AG (CH) 2001-09-18 US disclosed
EP-0942903-A1 ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY Novartis AG (CH) 1999-09-22 EP disclosed
WO-1998013347-A1 ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY NOVARTIS AG (CH) 1998-04-02 WO disclosed