Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 16/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 16/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1881373 | 0.88 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL7980154 | 0.85 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1877637 | 0.85 | BRD4 (0.58) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1875662 | 0.84 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1877931 | 0.82 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL6909151 | 0.82 | BRD4 (0.46) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1879729 | 0.81 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1880820 | 0.81 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1881963 | 0.81 | PARP10 (0.61) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1877041 | 0.80 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135651-A1 | 6-PYRIDIN-3-YL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN ALDOSTERONE SYNTHASE CYP11B2 | UNIVERSITÄT SAARLANDES (DE) | 2009-11-12 | — | — | WO | disclosed |