Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 15/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877637 | 0.87 | BRD4 (0.58) | BRD4CYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL1880707 | 0.84 | CYP11B2 (0.48) | BRD4CYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL1877041 | 0.84 | CYP11B1 (0.51) | BRD4CYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL7990636 | 0.82 | CYP11B1 (0.53) | BRD4CYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL1881373 | 0.80 | CYP11B1 (0.54) | BRD4CYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL1877931 | 0.74 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1879729 | 0.74 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1881963 | 0.73 | PARP10 (0.61) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1880820 | 0.73 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL1875662 | 0.73 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541404-B2 | Inhibitors of the human aldosterone synthase CYP11B2 | ELEXOPHARM GMBH (DE) | 2013-09-24 | — | — | US | disclosed |
| US-20110118241-A1 | 6-Pyridin-3-YL-3,4-Dihydro-1H-Quinolin-2-One Derivatives and Related Compounds as Inhibitors of the Human Aldosterone Synthase CYP11B2 | UNIVERSITAT DES SAARLANDES (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110112067-A1 | Inhibitors of the Human Aldosterone Sythase CYP11B2 | UNIVERSITAT DES SAARLANDES (DE) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118241-A1 | 6-Pyridin-3-YL-3,4-Dihydro-1H-Quinolin-2-One Derivatives and Related Compounds as Inhibitors of the Human Aldosterone Synthase CYP11B2 | HSD11B1, HSD11B2, CYP4A11 | BRD4 1721/4885CYP11B1 6/4885CYP11B2 4/4885 |
| US-20110112067-A1 | Inhibitors of the Human Aldosterone Sythase CYP11B2 | HSD11B1, HSD11B2, CYP11B1 | BRD4 4059/4885CYP11B1 3/4885CYP11B2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.