Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 3/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651699 | 0.90 | CYP2E1 (0.50) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL2910946 | 0.87 | CYP2E1 (0.67) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL17874829 | 0.87 | TLR8 (0.52) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL14249846 | 0.83 | SMN1; SMN2 (0.49) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL10981815 | 0.83 | KDM5A (0.50) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL8204568 | 0.82 | CYP2A6 (0.80) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL12985709 | 0.82 | PDE10A (0.49) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL12985345 | 0.82 | PDE10A (0.49) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL4865471 | 0.82 | PDE10A (0.49) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| Hydrochloric Acid SCHEMBL28812335 | 0.81 | PDE10A (0.48) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044208-A1 | ERYTHROMYCIN DERIVATIVES | Pfizer Products Inc. (US) | 2000-10-18 | — | — | EP | claimed |
| WO-1999035157-A1 | NOVEL ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-07-15 | — | — | WO | claimed |
| US-6291656-B1 | ANTIBIOTIC AGENTS FOR USE IN MAMMALS, HUMANS, FISH AND BIRDS; VETERINARY MEDICINE | PFIZER INC. | 2001-09-18 | — | — | US | disclosed |
| US-6159945-A | 9-amino-3-keto erythromycin derivatives | PFIZER INC. (US) | 2000-12-12 | — | — | US | disclosed |
| WO-1999021865-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| WO-1999021866-A1 | 9-AMINO-3-KETO ERYTHROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-05-06 | — | — | WO | disclosed |