Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | FLT1 | P17948 | 4/20 | 0.54 |
| ▸ | FLT4 | P35916 | 4/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HSPA9 | P38646 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | BMP4 | P12644 | 1/20 | 0.37 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551303 | 0.92 | KDR (0.52) | KDRFLT1FLT4MAPK13MAPK12 | |
| SCHEMBL7551949 | 0.91 | KDR (0.55) | KDRFLT1FLT4HRH2HRH1 | |
| SCHEMBL7547227 | 0.90 | KDR (0.60) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7550710 | 0.88 | KDR (0.52) | KDRFLT1FLT4GSK3BDRD2 | |
| SCHEMBL7545638 | 0.86 | KDR (0.72) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7988086 | 0.86 | KDR (0.51) | KDRFLT1FLT4MAPK14HRH3 | |
| SCHEMBL7987884 | 0.85 | KDR (0.52) | KDRFLT1FLT4MAPK13MAPK12 | |
| SCHEMBL7548789 | 0.85 | KDR (0.55) | KDRFLT1FLT4MAPK13MAPK12 | |
| SCHEMBL7549006 | 0.84 | KDR (0.75) | KDRFLT1FLT4GSK3BDRD2 | |
| SCHEMBL7556474 | 0.84 | KDR (0.61) | KDRFLT1FLT4MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |