Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 2/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546697 | 0.93 | KDR (0.53) | KDRGSK3BQPCTPRKCAPRKCB | |
| SCHEMBL7976106 | 0.91 | KDR (0.58) | KDRPRKCAPRKCBPRKCEFLT3 | |
| SCHEMBL7988211 | 0.90 | KDR (0.53) | KDRGSK3BQPCTPRKCAPRKCB | |
| SCHEMBL7550679 | 0.89 | KDR (0.67) | KDRGSK3BQPCTPRKCAPRKCB | |
| SCHEMBL7550957 | 0.88 | KDR (0.62) | KDRPRKCAPRKCBPRKCEFLT3 | |
| SCHEMBL7993991 | 0.87 | KDR (0.53) | KDRGSK3BQPCTPRKCAPRKCB | |
| SCHEMBL7987071 | 0.87 | KDR (0.56) | KDRGSK3BQPCTFLT3PRKD1 | |
| SCHEMBL7990452 | 0.85 | KDR (0.58) | KDRGSK3BPRKCAPRKCBPRKCE | |
| SCHEMBL7548808 | 0.85 | KDR (0.54) | KDRGSK3BQPCTTDP1FLT1 | |
| SCHEMBL7552517 | 0.85 | KDR (0.56) | KDRGSK3BQPCTTDP1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |