Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | PRKCA | P17252 | 2/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 2/20 | 0.41 |
| ▸ | ICMT | O60725 | 2/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991002 | 0.93 | KDR (0.53) | KDRGSK3BPRKCAPRKD1TDP1 | |
| SCHEMBL7993991 | 0.93 | KDR (0.53) | KDRGSK3BPRKCAPRKD1TDP1 | |
| SCHEMBL7987071 | 0.93 | KDR (0.56) | KDRGSK3BPRKD1TDP1QPCT | |
| SCHEMBL7987952 | 0.91 | KDR (0.58) | KDRPRKCAICMTPRKCBPRKCE | |
| SCHEMBL7990591 | 0.90 | KDR (0.53) | KDRGSK3BPRKCAPRKD1TDP1 | |
| SCHEMBL7550679 | 0.89 | KDR (0.67) | KDRGSK3BPRKCAPRKD1TDP1 | |
| SCHEMBL7986701 | 0.88 | KDR (0.53) | KDRGSK3BPRKD1TDP1QPCT | |
| SCHEMBL7554248 | 0.88 | KDR (0.62) | KDRPRKCAPRKD1TDP1PRKCB | |
| SCHEMBL7990759 | 0.87 | KDR (0.51) | KDRGSK3BPRKD1TDP1QPCT | |
| SCHEMBL7512866 | 0.86 | KDR (0.60) | KDRGSK3BPRKD1TDP1QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |