Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | KIF5B | P33176 | 2/20 | 0.49 |
| ▸ | FBP1 | P09467 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867169 | 0.91 | KDR (0.58) | EGFRKDRRETKIF5BAURKA | |
| SCHEMBL13604740 | 0.81 | EGFR (0.66) | EGFRERBB2ERBB4KDRRET | |
| Hydrochloric Acid SCHEMBL8707248 | 0.80 | EGFR (0.55) | EGFRERBB2ERBB4KDRRET | |
| SCHEMBL14979614 | 0.72 | EGFR (0.71) | EGFRERBB2ERBB4KDRRET | |
| SCHEMBL7452247 | 0.71 | MAPK14 (0.58) | EGFRKDRRETKIF5B | |
| SCHEMBL4477758 | 0.71 | EGFR (0.77) | EGFRERBB2ERBB4KDRRET | |
| SCHEMBL14388116 | 0.71 | FBP1 (0.59) | EGFRERBB2ERBB4KDRRET | |
| Hydrochloric Acid SCHEMBL8808763 | 0.71 | EGFR (0.77) | EGFRERBB2ERBB4KDRRET | |
| Hydrochloric Acid SCHEMBL8811939 | 0.71 | EGFR (0.71) | EGFRERBB2ERBB4KDRRET | |
| SCHEMBL7973114 | 0.70 | KDR (0.59) | EGFRERBB2KDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |