Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 2/20 | 0.61 |
| ▸ | GRM8 | O00222 | 2/20 | 0.61 |
| ▸ | GRM6 | O15303 | 2/20 | 0.61 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.61 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.61 |
| ▸ | GSR | P00390 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.61 |
| ▸ | GRM5 | P41594 | 1/20 | 0.61 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.61 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.61 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.61 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.61 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.61 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7991504 | 1.00 | SLC1A1 (0.61) | SLC1A1GRM8GRM6GRM7GRM4 | |
| Glutarate SCHEMBL28156974 | 0.90 | SLC1A1 (0.56) | SLC1A1GRM8GRM6GRM7GRM4 | |
| Alpha-Ketoglutaric Acid SCHEMBL1471949 | 0.89 | EGLN1 (0.58) | SLC1A1GRM8GRM6GRM7GRM4 | |
| Serine SCHEMBL6520912 | 0.89 | SLC1A1 (0.59) | SLC1A1GRM8GRM6GRM7GRM4 | |
| Serine SCHEMBL2023739 | 0.89 | SLC1A1 (0.59) | SLC1A1GRM8GRM6GRM7GRM4 | |
| Serine SCHEMBL1332181 | 0.89 | — | — | |
| Serine SCHEMBL6929773 | 0.89 | SLC1A1 (0.59) | SLC1A1GRM8GRM6GRM7GRM4 | |
| (D)-Serine SCHEMBL43094 | 0.89 | — | — | |
| Serine SCHEMBL6929758 | 0.89 | SLC1A1 (0.59) | SLC1A1GRM8GRM6GRM7GRM4 | |
| Serine SCHEMBL4455818 | 0.89 | SLC1A1 (0.59) | SLC1A1GRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792170-A4 | RADIONUCLIDE METAL CHELATES FOR THE RADIOLABELING OF LIGANDS, ANTI-LIGANDS OR OTHER PROTEINS | NEORX CORP (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0792170-A1 | RADIONUCLIDE METAL CHELATES FOR THE RADIOLABELING OF LIGANDS, ANTI-LIGANDS OR OTHER PROTEINS | NEORX CORPORATION (US) | 1997-09-03 | — | — | EP | claimed |
| WO-1995002418-A1 | RADIONUCLIDE METAL CHELATES FOR THE RADIOLABELING OF LIGANDS, ANTI-LIGANDS OR OTHER PROTEINS | NEORX CORPORATION (US) | 1995-01-26 | — | — | WO | claimed |
| US-5783171-A | Radionuclide metal N2 S2 chelates substituted with glucose and biotin moieties | NEORX CORPORATION (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0461245-A4 | RADIOLABELED PROTEINS FOR DIAGNOSTIC OR THERAPEUTIC USE | GUSTAVSON LINDA M (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5175257-A | Radiolabeled proteins for diagnostic or therapeutic use | NEORX CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |
| US-5112953-A | RADIOLABELED PROTEINS FOR DIAGNOSTIC OR THERAPEUTIC USE | NEORX CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0461245-A1 | RADIOLABELED PROTEINS FOR DIAGNOSTIC OR THERAPEUTIC USE | NEORX CORPORATION (US) | 1991-12-18 | — | — | EP | disclosed |
| WO-1991009876-A1 | RADIOLABELED PROTEINS FOR DIAGNOSTIC OR THERAPEUTIC USE | NEORX CORPORATION (US) | 1991-07-11 | — | — | WO | disclosed |