SCHEMBL7991663

SCHEMBL7991663

CC(C)(C)OC(=O)NCCc1nc(=O)c2c(ncn2Cc2ccccc2)[nH]1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CNOT7 Q9UIV1 2/20 0.45
PARN O95453 1/20 0.45
HPGD P15428 1/20 0.41
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
BCHE P06276 1/20 0.40
P2RX7 Q99572 1/20 0.40
IDO1 P14902 2/20 0.39
NPFFR1 Q9GZQ6 1/20 0.39
NPFFR2 Q9Y5X5 1/20 0.39
SIGMAR1 Q99720 3/20 0.39
AKT1 P31749 1/20 0.39
GNRHR P30968 1/20 0.39
NAMPT P43490 1/20 0.38
CKS1B P61024 1/20 0.38
SKP1 P63208 1/20 0.38
SKP2 Q13309 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7985296 0.94 PARN (0.44) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7985704 0.86 CNOT7 (0.50) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7991666 0.86 SMN1; SMN2 (0.53) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7988921 0.83 CNOT7 (0.44) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7974030 0.82 CNOT7 (0.42) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7987705 0.82 CNOT7 (0.51) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7985460 0.81 CNOT7 (0.45) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7985298 0.81 ALDH1A1 (0.52) CNOT7PARNHPGDALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL7987861 0.81 CNOT7 (0.50) CNOT7PARNHPGDALDH1A1SMN1; SMN2
SCHEMBL7974180 0.80 CNOT7 (0.44) CNOT7PARNHPGDALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6310070-B1 FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS JAPAN ENERGY CORPORATION (JP) 2001-10-30 US disclosed
EP-0999211-A1 NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF JAPAN ENERGY CORPORATION (JP) 2000-05-10 EP disclosed