Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.63 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | CDC7 | O00311 | 4/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | MELK | Q14680 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857720 | 0.91 | CAMKK2 (0.64) | CAMKK2NEK2PLK1NEK1DYRK1A | |
| SCHEMBL857846 | 0.81 | CAMKK2 (0.69) | CAMKK2PLK1DYRK1ACDC7MAP4K4 | |
| SCHEMBL8939859 | 0.78 | CAMKK2 (1.00) | CAMKK2NEK2PLK1DYRK1ACDC7 | |
| SCHEMBL22044122 | 0.75 | CAMKK2 (0.72) | CAMKK2NEK2PLK1DYRK1ACDC7 | |
| SCHEMBL858529 | 0.74 | CAMKK2 (0.67) | CAMKK2NEK2PLK1DYRK1ACDC7 | |
| SCHEMBL858398 | 0.74 | NEK1 (0.72) | NEK1ROCK2 | |
| SCHEMBL31370271 | 0.74 | CAMKK2 (0.62) | CAMKK2NEK2PLK1DYRK1ACDC7 | |
| SCHEMBL22044118 | 0.73 | CAMKK2 (0.55) | CAMKK2DYRK1ACDC7MAP4K4CLK4 | |
| SCHEMBL857695 | 0.73 | CAMKK2 (0.59) | CAMKK2DYRK1ACDC7MAP4K4CLK4 | |
| SCHEMBL858447 | 0.72 | CAMKK2 (0.56) | CAMKK2DYRK1ACDC7MAP4K4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | CAMKK2 103/4885NEK2 325/4885PLK1 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.