Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936653 | 0.88 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL937180 | 0.84 | PIK3CG (0.65) | PIK3CGPIK3CDPIK3CAPIK3CBMAP4K4 | |
| SCHEMBL1933631 | 0.83 | PIK3CG (0.47) | PIK3CGPIK3CDPIK3CAPIK3CBDYRK1B | |
| SCHEMBL1932107 | 0.83 | PIK3CG (0.47) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL12554043 | 0.81 | PIK3CG (0.53) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL12970648 | 0.80 | PIK3CG (0.54) | PIK3CGPIK3CDPIK3CAPIK3CBJAK2 | |
| SCHEMBL936441 | 0.80 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CAPIK3CBJAK2 | |
| SCHEMBL938836 | 0.80 | PIK3CG (0.48) | PIK3CGPIK3CDPIK3CAPIK3CBMAP4K4 | |
| SCHEMBL1933524 | 0.79 | PIK3CG (0.50) | PIK3CGPIK3CDPIK3CAPIK3CBJAK2 | |
| SCHEMBL12554057 | 0.77 | PIK3CG (0.48) | PIK3CGPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | MTOR, STAT3, SLC14A1 | PIK3CG 16/4885DHFR 4321/4885PIK3CD 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.