SCHEMBL7992293

SCHEMBL7992293

CCOC(=O)Cn1ncc2c1CCN(C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OC(C)(C)C)C2

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 2/20 0.46
ITGB3 P05106 1/20 0.44
ITGA2B P08514 1/20 0.44
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
P2RX7 Q99572 3/20 0.38
ALDH1A1 P00352 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
KMT2A Q03164 3/20 0.37
ITGA4 P13612 1/20 0.36
ITGB7 P26010 1/20 0.36
PARP1 P09874 1/20 0.36
HRH2 P25021 2/20 0.35
HRH1 P35367 2/20 0.35
MAPK1 P28482 1/20 0.35
HCRTR2 O43614 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7988438 0.86 ADORA1 (0.48) ADORA1ITGB3ITGA2BPPARGPPARA
SCHEMBL7988313 0.85 ITGB3 (0.59) ADORA1ITGB3ITGA2BPPARGPPARA
SCHEMBL7992197 0.85 ITGB3 (0.63) ITGB3ITGA2BP2RX7ALDH1A1RAB9A
SCHEMBL7985147 0.85 ADORA1 (0.48) ADORA1ITGB3ITGA2BPPARGPPARA
SCHEMBL7975256 0.85 ITGB3 (0.44) ADORA1ITGB3ITGA2BP2RX7ALDH1A1
Hydrochloric Acid SCHEMBL7986126 0.84 ITGB3 (0.62) ITGB3ITGA2BP2RX7ALDH1A1RAB9A
Trifluoroacetic Acid SCHEMBL7989366 0.84 ITGB3 (0.61) ADORA1ITGB3ITGA2BP2RX7RAB9A
SCHEMBL7985928 0.84 ADORA1 (0.48) ADORA1ITGB3ITGA2BPPARGPPARA
SCHEMBL7985559 0.80 ADORA1 (0.50) ADORA1ITGB3ITGA2BPPARGPPARA
SCHEMBL7987546 0.78 ADORA1 (0.47) ADORA1P2RX7KMT2AITGA4ITGB7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed