Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 12/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.48 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982648 | 0.89 | OPRL1 (0.77) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7982598 | 0.86 | OPRL1 (0.77) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL29766745 | 0.86 | OPRL1 (1.00) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7757872 | 0.86 | OPRL1 (1.00) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7982285 | 0.84 | OPRL1 (0.69) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7999841 | 0.82 | OPRL1 (0.69) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL29789407 | 0.82 | MEN1 (1.00) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7992840 | 0.82 | MEN1 (1.00) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7757095 | 0.81 | OPRL1 (0.83) | OPRL1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7992799 | 0.81 | OPRL1 (0.75) | OPRL1MEN1KMT2ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | disclosed |