Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.57 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29789407 | 1.00 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7995842 | 0.89 | CYP2D6 (0.80) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7995949 | 0.88 | MEN1 (0.79) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7759170 | 0.87 | MEN1 (0.77) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7982605 | 0.86 | MEN1 (0.76) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7760221 | 0.85 | MEN1 (0.75) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7994167 | 0.85 | MEN1 (0.74) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7982648 | 0.85 | OPRL1 (0.77) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7754132 | 0.84 | MEN1 (0.72) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7760219 | 0.84 | MEN1 (0.72) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | disclosed |