SCHEMBL7992973

SCHEMBL7992973

CCCOc1cc(C)ccc1C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.51
PLK1 P53350 3/20 0.48
ALDH1A1 P00352 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
NPBWR1 P48145 1/20 0.46
MCHR1 Q99705 1/20 0.46
ADRB1 P08588 2/20 0.46
ADRB3 P13945 2/20 0.46
CYP1A2 P05177 2/20 0.46
TTR P02766 1/20 0.46
CYP2C8 P10632 1/20 0.46
CHRM1 P11229 1/20 0.46
CYP2C9 P11712 1/20 0.46
ADRA1A P35348 1/20 0.46
PPARG P37231 1/20 0.46
HTR2B P41595 1/20 0.46
PPARA Q07869 1/20 0.46
SLCO1B3 Q9NPD5 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CISD1 Q9NZ45 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11776705 0.93 TSHR (0.55) TSHRPLK1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL22435071 0.87 TSHR (0.49) TSHRPLK1ALDH1A1SMN1; SMN2NPBWR1
SCHEMBL31325081 0.87 TSHR (0.51) TSHRPLK1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL11078865 0.87 PTPN11 (0.52) TSHRPLK1ALDH1A1SMN1; SMN2TDP1
SCHEMBL13951455 0.87 TSHR (0.51) TSHRPLK1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL23267707 0.87 SMN1; SMN2 (0.56) TSHRALDH1A1SMN1; SMN2NPBWR1MCHR1
SCHEMBL6646454 0.86 TSHR (0.53) TSHRPLK1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL7307065 0.85 TSHR (0.46) TSHRALDH1A1SMN1; SMN2NPBWR1MCHR1
SCHEMBL7960697 0.85 MAPT (0.51) TSHRALDH1A1SMN1; SMN2NPBWR1MCHR1
SCHEMBL28529318 0.85 KMT2A (0.57) TSHRALDH1A1ADRB1ADRB3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240027903-A1 Resist Material And Patterning Process SHIN-ETSU CHEMICAL CO., LTD. (JP) 2024-01-25 US disclosed
US-11839613-B2 Pyrimidine derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2023-12-12 US disclosed
US-11839613-B2 Pyrimidine derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2023-12-12 US disclosed
US-11712438-B2 Phenyl derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2023-08-01 US disclosed
US-11712438-B2 Phenyl derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2023-08-01 US disclosed
US-20220175775-A1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2022-06-09 US disclosed
US-11325899-B2 Benzofurane and benzothiophene derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2022-05-10 US disclosed
EP-3928836-A1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS Idorsia Pharmaceuticals Ltd (CH) 2021-12-29 EP disclosed
EP-3625223-B1 PYRIMIDINE DERIVATIVES IDORSIA PHARMACEUTICALS LTD (CH) 2021-08-11 EP disclosed
EP-3625222-B1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2021-07-21 EP disclosed
EP-3625228-B1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2021-07-07 EP disclosed
US-20210113559-A1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2021-04-22 US disclosed
US-20210115031-A1 BENZOFURANE AND BENZOTHIOPHENE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2021-04-22 US disclosed
US-20200289507-A1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2020-09-17 US disclosed
US-20200179383-A1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS ACTELION PHARMACEUTICALS LTD (CH) 2020-06-11 US disclosed
US-20200108068-A1 PYRIMIDINE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2020-04-09 US disclosed
EP-0982621-B1 Film for optical elements NIPPON MITSUBISHI OIL CORP (JP) 2012-10-10 EP disclosed
US-6294229-B1 Film for optical elements NIPPON MITSUBISHI OIL COMPANY (JP) 2001-09-25 US disclosed
EP-0982621-A2 Film for optical elements Nippon Mitsubishi Oil Corporation (JP) 2000-03-01 EP disclosed
US-3985891-A CARDIOTONICS, ANTICOAGULANTS BOEHRINGER INGELHEIM GMBH (DT) 1976-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11712438-B2 Phenyl derivatives as PGE2 receptor modulators PTGER1, PTGER4, PTGER2 TSHR 494/4885PLK1 4432/4885ALDH1A1 575/4885
US-20200289507-A1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER1, PTGER4, PTGER2 TSHR 325/4885PLK1 4139/4885ALDH1A1 761/4885
US-20220175775-A1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER1, PTGER4, PTGER2 TSHR 325/4885PLK1 4139/4885ALDH1A1 761/4885
US-20200179383-A1 PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER1, PTGER4, PTGER2 TSHR 497/4885PLK1 4410/4885ALDH1A1 527/4885
US-11839613-B2 Pyrimidine derivatives as PGE2 receptor modulators PTGER1, PTGER4, PTGER2 TSHR 654/4885PLK1 4022/4885ALDH1A1 468/4885
US-20210113559-A1 PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER1, PTGER4, PTGER2 TSHR 654/4885PLK1 4022/4885ALDH1A1 468/4885
US-20210115031-A1 BENZOFURANE AND BENZOTHIOPHENE DERIVATIVES AS PGE2 RECEPTOR MODULATORS PTGER4, PTGER1, PTGER2 TSHR 704/4885PLK1 4692/4885ALDH1A1 477/4885
US-20240027903-A1 Resist Material And Patterning Process LBR, HNRNPU, EWSR1 TSHR 2364/4885PLK1 4757/4885ALDH1A1 4741/4885
US-20200108068-A1 PYRIMIDINE DERIVATIVES PTGER1, PTGER4, PTGER2 TSHR 1074/4885PLK1 4208/4885ALDH1A1 418/4885
US-11325899-B2 Benzofurane and benzothiophene derivatives as PGE2 receptor modulators PTGER4, PTGER1, PTGER2 TSHR 704/4885PLK1 4692/4885ALDH1A1 477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.