Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.65 |
| ▸ | GCGR | P47871 | 14/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.62 |
| ▸ | FRK | P42685 | 4/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.62 |
| ▸ | GSK3B | P49841 | 4/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.62 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.62 |
| ▸ | PRKACA | P17612 | 3/20 | 0.57 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553380 | 0.82 | ALOX5 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL13497841 | 0.81 | MAPK11 (0.76) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2648503 | 0.80 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL15075603 | 0.79 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL19868925 | 0.79 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL13497913 | 0.78 | ALOX5 (0.71) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL9193657 | 0.78 | MAPK13 (0.72) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2648771 | 0.78 | MAPK13 (0.72) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL4551864 | 0.77 | ALOX5 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2649542 | 0.77 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288089-B1 | ADMINISTERING A COMPOSITION OF PYRIDYL IMIDAZOLE COMPOUNDS TO TREAT PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, ALZHEIMER'S DISEASE, AND AMYOTOPHIC LATERAL SCLEROSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-09-11 | — | — | US | disclosed |