Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | MAX | P61244 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789091 | 0.84 | NPC1 (0.68) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL527978 | 0.81 | MYC (0.70) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL5794222 | 0.81 | CNR2 (0.54) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL15249113 | 0.81 | MEN1 (0.66) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9446245 | 0.79 | MEN1 (0.64) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL7982492 | 0.79 | NPC1 (0.60) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL3295875 | 0.77 | CYP19A1 (0.65) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL7228750 | 0.77 | MAPT (0.61) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL20222275 | 0.76 | ALDH1A1 (0.65) | NPC1RAB9ARECQLALDH1A1KMT2A | |
| SCHEMBL810591 | 0.76 | NPC1 (0.51) | NPC1RAB9AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |