Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975962 | 0.88 | EDNRA (0.56) | MAPK9KMT2AEDNRAOGATP53 | |
| SCHEMBL31062585 | 0.75 | AKR1C3 (0.66) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL14537417 | 0.75 | AKR1C3 (0.66) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL7835310 | 0.75 | AKR1C3 (0.66) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL7975875 | 0.74 | MAPK9 (0.61) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL6367096 | 0.73 | MAPK9 (0.68) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL6367100 | 0.73 | MAPK9 (0.68) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL8808534 | 0.73 | MAPK9 (0.51) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL2183809 | 0.72 | MAPK9 (0.63) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 | |
| SCHEMBL6985620 | 0.72 | MAPK9 (0.66) | MAPK9CYP1A2CYP2C9CYP2C19AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |