Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.40 |
| ▸ | OGA | O60502 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993449 | 0.88 | MAPK9 (0.51) | EDNRAKMT2AMCHR1MAPK9CYP26A1 | |
| SCHEMBL21656188 | 0.75 | EDNRA (0.62) | EDNRAKMT2AMAPK9TAS1R3TAS1R1 | |
| SCHEMBL8810457 | 0.74 | EDNRA (0.56) | EDNRAKMT2AMAPK9TAS1R3TAS1R1 | |
| SCHEMBL7987643 | 0.74 | MAPK1 (0.51) | — | |
| SCHEMBL7498975 | 0.72 | EDNRA (0.58) | EDNRAKMT2AMAPK9TAS1R3TAS1R1 | |
| SCHEMBL7986471 | 0.71 | EDNRA (0.54) | EDNRAOPRM1OPRD1 | |
| SCHEMBL22404286 | 0.71 | EDNRA (0.56) | EDNRAKMT2ATAS1R3TAS1R1MEN1 | |
| SCHEMBL1746047 | 0.70 | PTGS2 (0.56) | EDNRAKMT2ATAS1R3TAS1R1MEN1 | |
| SCHEMBL805660 | 0.70 | EDNRA (0.55) | EDNRAKMT2ATAS1R3TAS1R1MEN1 | |
| SCHEMBL25762086 | 0.70 | CYP11B1 (0.36) | KMT2ATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |