Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 12/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 4/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652284 | 0.85 | TYMS (0.58) | TYMSKDM4ELMNAHSD17B10ALDH1A1 | |
| SCHEMBL6653100 | 0.79 | TYMS (1.00) | TYMSKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL6652380 | 0.78 | TYMS (1.00) | TYMSPARP1 | |
| SCHEMBL12909164 | 0.78 | ALDH1A1 (0.63) | KDM4EHSD17B10ALDH1A1HPGDNPC1 | |
| SCHEMBL6450968 | 0.78 | TYMS (0.73) | TYMSPARP1 | |
| SCHEMBL6650462 | 0.75 | TYMS (1.00) | TYMSPARP1 | |
| SCHEMBL6651474 | 0.75 | TYMS (1.00) | TYMSALDH1A1PARP1 | |
| SCHEMBL6650293 | 0.75 | TYMS (1.00) | TYMSPARP1 | |
| SCHEMBL6652840 | 0.73 | TYMS (0.59) | TYMSNPC1GAAMAPTRAB9A | |
| SCHEMBL6649424 | 0.72 | TYMS (0.64) | TYMSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306865-B1 | SYNTHASE INHIBITORS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-10-23 | — | — | US | disclosed |