Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17676750 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL1608468 | 0.91 | PTPN1 (0.45) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL17676749 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL1608209 | 0.80 | MAPT (0.56) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL1608510 | 0.80 | SMN1; SMN2 (0.51) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL1607834 | 0.80 | HDAC1 (0.44) | KDM4EALDH1A1CYP2C19KMT2APOLB | |
| SCHEMBL1607755 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL1608799 | 0.78 | MAPT (0.56) | KDM4EALDH1A1HPGDLMNACYP3A4 | |
| SCHEMBL8003723 | 0.77 | HDAC8 (0.43) | SMN1; SMN2PTPN1TSHRHTTTP53 | |
| SCHEMBL1809364 | 0.75 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009129335-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-10-22 | — | — | WO | disclosed |