Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575679 | 1.00 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4575840 | 1.00 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL6374535 | 1.00 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4575933 | 1.00 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4576016 | 1.00 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL7923037 | 1.00 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL13440481 | 0.94 | OPRD1 (0.64) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL6933103 | 0.92 | OPRD1 (0.67) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL6933099 | 0.92 | OPRD1 (0.67) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL6933102 | 0.92 | OPRD1 (0.67) | OPRD1CYP1A2CYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003373-A4 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1003373-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-2000009508-A1 | TRIAZOLOPYRIMIDINE DERIVATIVES | NIHON BAYER AGROCHEM K.K. (DE) | 2000-02-24 | — | — | WO | disclosed |
| US-5985880-A | REDUCING, TREATING OR PREVENTING DRUG-MEDIATED RESPIRATORY DEPRESSION IN AN ANIMAL BY ADMINISTERING A .DELTA. RECEPTOR AGONIST COMPOUND | DELTA PHARMACEUTICALS (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1999001033-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |