Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 6/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971936 | 0.87 | TRPV4 (0.47) | TRPV4MC4RDPP7HRH1SLC6A15 | |
| SCHEMBL4972317 | 0.81 | TRPV4 (0.68) | TRPV4CCR1 | |
| SCHEMBL8010445 | 0.81 | TRPV4 (0.68) | TRPV4CCR1 | |
| SCHEMBL5007983 | 0.81 | CCR1 (0.39) | TRPV4CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL13994300 | 0.77 | STS (0.45) | — | |
| SCHEMBL4972801 | 0.76 | TRPV4 (0.69) | TRPV4CCR1 | |
| SCHEMBL5004460 | 0.76 | TRPV4 (0.53) | TRPV4MC4RMAPTCCR1 | |
| SCHEMBL13994327 | 0.74 | TRPV4 (0.52) | TRPV4CYP3A4MC4RCCR1 | |
| SCHEMBL8006832 | 0.74 | TRPV4 (0.58) | TRPV4CCR1 | |
| SCHEMBL4975527 | 0.73 | TRPV4 (0.66) | TRPV4MC4RDPP7HRH1SLC6A15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |