Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13654280 | 1.00 | HSD17B10 (0.49) | HSD17B10GLAGAAALDH1A1MAPK1 | |
| SCHEMBL13654279 | 1.00 | HSD17B10 (0.49) | HSD17B10GLAGAAALDH1A1MAPK1 | |
| SCHEMBL18434008 | 0.86 | — | — | |
| SCHEMBL1871672 | 0.83 | ALDH1A1 (0.49) | HSD17B10ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL13654356 | 0.83 | ALDH1A1 (0.49) | HSD17B10ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL20284513 | 0.83 | ALDH1A1 (0.49) | HSD17B10ALDH1A1LMNAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL25419006 | 0.81 | ALDH1A1 (0.51) | HSD17B10ALDH1A1LMNAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL25419008 | 0.81 | ALDH1A1 (0.51) | HSD17B10ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL19815496 | 0.78 | ALDH1A1 (0.47) | HSD17B10GLAGAAALDH1A1MAPK1 | |
| SCHEMBL7362051 | 0.77 | ALDH1A1 (0.58) | HSD17B10GLAGAAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2578571-B1 | Isoquinoline modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |