Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | STAT6 | P42226 | 6/20 | 0.35 |
| ▸ | STAT5A | P42229 | 3/20 | 0.35 |
| ▸ | STAT5B | P51692 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995567 | 0.93 | TRPV4 (0.42) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL7995230 | 0.93 | TRPV4 (0.41) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL8007338 | 0.91 | TRPV4 (0.41) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL8004239 | 0.91 | TRPV4 (0.40) | TRPV4CCR1STAT6STAT5ASTAT5B | |
| SCHEMBL8007063 | 0.90 | TRPV4 (0.42) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL8007066 | 0.90 | TRPV4 (0.42) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL8007203 | 0.90 | CCR1 (0.39) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL8006940 | 0.90 | CCR1 (0.37) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL7995042 | 0.88 | NPY5R (0.42) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL8005360 | 0.87 | STAT6 (0.39) | TRPV4CCR1STAT6STAT5ASTAT5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |