SCHEMBL7996211

SCHEMBL7996211

COc1cc(-c2nc3cc(C(=O)c4ccccc4)ccc3[nH]2)ccc1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 2/20 0.59
CYP1B1 Q16678 2/20 0.59
CYP1A2 P05177 1/20 0.59
NOX1 Q9Y5S8 2/20 0.56
PARP1 P09874 1/20 0.53
PDE4A P27815 4/20 0.50
PDE4B Q07343 4/20 0.50
PDE4C Q08493 4/20 0.50
PDE4D Q08499 4/20 0.50
CHEK2 O96017 3/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
SLC22A6 Q4U2R8 1/20 0.49
SLC22A8 Q8TCC7 1/20 0.49
SMPD3 Q9NY59 1/20 0.48
GUSB P08236 1/20 0.48
CHEK1 O14757 1/20 0.48
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.47
ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12470812 0.89 CYP1A1 (0.58) CYP1A1CYP1B1CYP1A2NOX1PARP1
SCHEMBL31737379 0.89 CYP1A1 (0.58) CYP1A1CYP1B1CYP1A2NOX1PARP1
SCHEMBL15224066 0.86 CYP1A1 (0.55) CYP1A1CYP1B1CYP1A2NOX1PARP1
SCHEMBL12392519 0.83 CYP1A1 (0.52) CYP1A1CYP1B1CYP1A2NOX1PARP1
SCHEMBL7986152 0.81 PDE4A (0.55) PDE4APDE4BPDE4CPDE4DCHEK2
SCHEMBL15456540 0.81 CYP1A1 (0.69) CYP1A1CYP1B1CYP1A2NOX1PARP1
SCHEMBL34467256 0.81 CHEK2 (0.64) CYP1A2CHEK2MEN1KMT2AKDM4E
SCHEMBL19994452 0.80 CHEK2 (0.64) CYP1A2CHEK2MEN1KMT2AKDM4E
SCHEMBL12471625 0.80 CYP1A1 (0.58) CYP1A1CYP1B1CYP1A2PARP1PDE4A
SCHEMBL15455891 0.79 PDE4A (0.65) PARP1PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288100-B1 SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION 2001-09-11 US claimed
EP-0830343-A1 BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-25 EP claimed
WO-1996039390-A1 BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION (US) 1996-12-12 WO claimed
US-6288100-B1 SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION 2001-09-11 US disclosed
EP-0830343-A1 BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-25 EP disclosed
WO-1996039390-A1 BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION (US) 1996-12-12 WO disclosed