Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.55 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996211 | 0.81 | CYP1A1 (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7151164 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DAMY1A | |
| SCHEMBL8000047 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DAMY1A | |
| SCHEMBL15455891 | 0.79 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DAMY1A | |
| SCHEMBL7334119 | 0.76 | RARB (0.62) | CHEK2 | |
| SCHEMBL14382293 | 0.76 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DAMY1A | |
| SCHEMBL13790358 | 0.75 | LTB4R (0.61) | POLBHPGDL3MBTL1LTB4RTHRA | |
| SCHEMBL7371345 | 0.74 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DCHEK2 | |
| SCHEMBL3560621 | 0.74 | KDM4E (0.66) | HPGDCHEK2MEN1KMT2A | |
| SCHEMBL34467256 | 0.74 | CHEK2 (0.64) | POLBHPGDCHEK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | claimed |
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |