Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lumateperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 18/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 1.00 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 15/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 0.83 |
| ▸ | DRD1 | P21728 | 1/20 | 0.83 |
| ▸ | DRD4 | P21917 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.83 |
| ▸ | CCR3 | P51677 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lumateperone SCHEMBL1468226 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| Lumateperone SCHEMBL21524899 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| Lumateperone SCHEMBL22067597 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| Lumateperone SCHEMBL29355930 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| Lumateperone SCHEMBL5513940 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| Lumateperone SCHEMBL17681371 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| Lumateperone SCHEMBL21707920 | 0.99 | HTR2A (0.98) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| SCHEMBL27288366 | 0.97 | HTR2A (0.95) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| SCHEMBL27290495 | 0.97 | HTR2A (0.95) | HTR2AHTR2CSLC6A4DRD2HTR1A | |
| SCHEMBL27290546 | 0.96 | HTR2A (0.93) | HTR2AHTR2CSLC6A4DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015085004-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. (US) | 2015-06-11 | — | — | WO | disclosed |
| WO-2009145900-A1 | METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS | INTRA-CELLULAR THERAPIES, INC. (US) | 2009-12-03 | — | — | WO | disclosed |