Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 14/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996817 | 1.00 | ADRB1 (0.59) | ADRB1ADRB3ADRB2HTR1ADRD2 | |
| SCHEMBL7993952 | 0.84 | ADRB3 (0.70) | ADRB1ADRB3ADRB2 | |
| SCHEMBL7993957 | 0.84 | ADRB3 (0.70) | ADRB1ADRB3ADRB2 | |
| SCHEMBL7989646 | 0.82 | ADRB3 (0.59) | ADRB1ADRB3ADRB2 | |
| SCHEMBL7989644 | 0.82 | ADRB3 (0.59) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6621605 | 0.81 | ADRB3 (0.68) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6621598 | 0.81 | ADRB3 (0.68) | ADRB1ADRB3ADRB2 | |
| Hydrochloric Acid SCHEMBL6620987 | 0.80 | ADRB3 (0.67) | ADRB1ADRB3ADRB2 | |
| Hydrochloric Acid SCHEMBL6620983 | 0.80 | ADRB3 (0.67) | ADRB1ADRB3ADRB2 | |
| SCHEMBL7989845 | 0.77 | ADRB1 (0.61) | ADRB1ADRB3ADRB2HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291491-B1 | TREATMENT OF TYPE II DIABETES AND OBESITY; ANTIDEPRESSANTS; DECREASE GUT MOTILITY. | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |