Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16622315 | 1.00 | ALDH1A1 (0.59) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL22224173 | 1.00 | ALDH1A1 (0.59) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL20231393 | 1.00 | ALDH1A1 (0.59) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL211904 | 0.98 | ALDH1A1 (0.56) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL20231694 | 0.94 | ALDH1A1 (0.53) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL20231684 | 0.94 | ALDH1A1 (0.53) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL20231685 | 0.92 | ALDH1A1 (0.52) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL1559633 | 0.91 | — | — | |
| SCHEMBL20230958 | 0.90 | TSHR (0.48) | ALDH1A1TSHRRECQLLMNAHDAC3 | |
| SCHEMBL20231689 | 0.88 | GAA (0.47) | ALDH1A1TSHRRECQLLMNAHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |