Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393183 | 1.00 | DRD2 (0.61) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL6559628 | 0.89 | DRD2 (0.59) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL13729821 | 0.80 | DRD2 (0.72) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL3780137 | 0.80 | DRD2 (0.68) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL20362100 | 0.78 | DRD2 (0.72) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL13729374 | 0.77 | DRD2 (1.00) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL8006961 | 0.77 | DRD2 (1.00) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL8008834 | 0.77 | DRD2 (0.80) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL8006320 | 0.77 | DRD2 (1.00) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL9885168 | 0.76 | SMN1; SMN2 (0.71) | DRD2ALDH1A1TP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105026-A1 | COMPOUND (R) -N*6*-ETHYL-6, 7-DIHYDRO-5H-INDENO (5, 6- D) THIAZOLE-2, 6-DIAMINE AND THE USE AS ANTIPSYCHOTICS | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | WO | disclosed |