Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9463543 | 0.77 | ATM (0.44) | MEN1KMT2AMAPTTDP1CYP1A2 | |
| SCHEMBL31012122 | 0.74 | CYP1A2 (0.56) | MEN1KMT2ATDP1CYP1A2CYP2C19 | |
| SCHEMBL4850585 | 0.74 | CYP1A2 (0.56) | MEN1KMT2ATDP1CYP1A2CYP2C19 | |
| SCHEMBL22169095 | 0.74 | ALDH1A1 (0.39) | MEN1KMT2AMAPTTDP1CYP1A2 | |
| SCHEMBL31634194 | 0.74 | ALDH1A1 (0.54) | MEN1KMT2AMAPTTDP1CYP1A2 | |
| SCHEMBL29237167 | 0.74 | NPC1 (0.50) | MEN1KMT2ATDP1CYP1A2CYP2C19 | |
| SCHEMBL13316754 | 0.73 | MEN1 (0.36) | MEN1KMT2AMAPTCYP1A2ALDH1A1 | |
| SCHEMBL9641021 | 0.72 | ALDH1A1 (0.61) | MEN1KMT2ATDP1EPHX1SLC1A3 | |
| SCHEMBL29816145 | 0.72 | MAPT (0.58) | MEN1KMT2AMAPTTDP1CYP1A2 | |
| SCHEMBL5609808 | 0.72 | NPC1 (0.64) | MEN1KMT2AMAPTTDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |