SCHEMBL7997008

SCHEMBL7997008

COc1cc(OC)cc(C(C)(C)[C]=O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
CYP1A1 P04798 6/20 0.38
CYP1B1 Q16678 6/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CYP1A2 P05177 3/20 0.34
CYP2E1 P05181 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C8 P10632 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2A6 P11509 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP4B1 P13584 2/20 0.34
CYP2B6 P20813 2/20 0.34
CYP3A5 P20815 2/20 0.34
CYP2A7 P20853 2/20 0.34
CYP3A7 P24462 2/20 0.34
CYP2F1 P24903 2/20 0.34
CYP2C18 P33260 2/20 0.34
CYP2C19 P33261 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3742483 0.78 CA1 (0.48) ALDH1A1CA1CA2CYP2A6GAA
SCHEMBL5055677 0.78 ALDH1A1 (0.48) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL9620 0.75 ALDH1A1 (0.44) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL8609777 0.75 CYP2A6 (0.47) ALDH1A1CA1CYP1A2CYP2A6KDM4E
SCHEMBL1376849 0.75 ALDH1A1 (0.55) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL278798 0.74 ALDH1A1 (0.61) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL3788801 0.72 ALDH1A1 (0.58) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL9132402 0.72 ALDH1A1 (0.58) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL21545657 0.71 ALDH1A1 (0.50) ALDH1A1CYP1A1CYP1B1CA1CA2
SCHEMBL23461935 0.71 ALDH1A1 (0.44) ALDH1A1CYP1A1CYP1B1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6075141-A N-ALPHA-PROTECTED AMINO ACID ESTER DERIVATIVES ARE USEFUL FOR MAKING PEPTIDES AND POLYPEPTIDES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2000-06-13 US claimed
US-6288038-B1 ACCELERATE APOLIPOPROTEIN E PRODUCTION; NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE; ANTILIPEMIC AGENTS NISSHIN SEIFUN GROUP INC. (JP) 2001-09-11 US disclosed
EP-1028126-A1 DEPSIPEPTIDE DERIVATIVES BEARING PIPERAZINONE RINGS Nisshin Flour Milling Co., Ltd. (JP) 2000-08-16 EP disclosed
US-6100394-A Long-lived homogenous oxidation catalysts CARNEGIE MELLON UNIVERSITY (US) 2000-08-08 US disclosed
US-6075141-A N-ALPHA-PROTECTED AMINO ACID ESTER DERIVATIVES ARE USEFUL FOR MAKING PEPTIDES AND POLYPEPTIDES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2000-06-13 US disclosed