Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440565 | 0.86 | SLC6A4 (0.45) | TDP1SLC6A3SLC6A2SLC6A4KDM1A | |
| SCHEMBL451958 | 0.86 | SLC6A4 (0.45) | TDP1SLC6A3SLC6A2SLC6A4KDM1A | |
| SCHEMBL13859341 | 0.86 | SLC9A1 (0.50) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL12894946 | 0.86 | SLC9A1 (0.50) | ALDH1A1LMNASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL12894947 | 0.86 | SLC9A1 (0.50) | ALDH1A1LMNASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL15314508 | 0.86 | SLC6A4 (0.45) | TDP1SLC6A3SLC6A2SLC6A4KDM1A | |
| SCHEMBL804952 | 0.86 | SLC9A1 (0.50) | ALDH1A1LMNASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL15977397 | 0.85 | MAPK1 (0.55) | ALDH1A1TDP1KDM1AMAPK1SMN1; SMN2 | |
| SCHEMBL15977398 | 0.85 | MAPK1 (0.55) | ALDH1A1TDP1KDM1AMAPK1SMN1; SMN2 | |
| SCHEMBL15977388 | 0.85 | MAPK1 (0.55) | ALDH1A1TDP1KDM1AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853390-B2 | Processes for preparing 1,2-substituted cyclopropyl derivatives | ABBVIE INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120071651-A1 | Processes for Preparing 1,2-Substituted Cyclopropyl Derivatives | ABBOTT LABORATORIES (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071651-A1 | Processes for Preparing 1,2-Substituted Cyclopropyl Derivatives | HRH3, HRH4, HRH1 | ALDH1A1 1799/4885CYP1A2 591/4885CYP3A4 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.