Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217260 | 0.84 | ALPL (0.64) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL5113642 | 0.82 | MAPK1 (0.58) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL7997998 | 0.80 | GRN (0.43) | ALPLGAAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL17479592 | 0.79 | MAPK1 (0.62) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL7230719 | 0.78 | MAPK1 (0.60) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL3202467 | 0.78 | MAPK1 (0.60) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL30107039 | 0.75 | MAPK1 (0.70) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL26927238 | 0.73 | MAPK1 (0.50) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL5111954 | 0.72 | GAA (0.56) | MAPK1ALPLRAB9ANPC1GAA | |
| SCHEMBL22574774 | 0.72 | MAPT (0.49) | MAPK1ALPLRAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |