Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998115 | 0.87 | LMNA (0.39) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL17919039 | 0.82 | LMNA (0.34) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL7999363 | 0.78 | LMNA (0.48) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL12649521 | 0.72 | DYRK1A (0.39) | LMNABLM | |
| SCHEMBL12599750 | 0.70 | CYP1A2 (0.47) | CYP1A2GAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8002182 | 0.70 | LMNA (0.54) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL11700170 | 0.70 | LMNA (0.39) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL11795651 | 0.67 | CYP1A2 (0.53) | LMNACYP1A2THRBBLMCREBBP | |
| SCHEMBL12599615 | 0.67 | — | — | |
| SCHEMBL9049274 | 0.67 | MAPT (0.38) | LMNACYP1A2GAAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288613-B1 | PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2009131975-A1 | PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE | SCHERING CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |