Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 3/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170233 | 0.87 | ALDH1A1 (0.65) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL7902024 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL7967064 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL614655 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL12633938 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL12633934 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL614654 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL12633937 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL7973199 | 0.85 | CA1 (0.56) | TSHRALDH1A1GAACA1CA2 | |
| SCHEMBL7898004 | 0.84 | CA1 (0.55) | TSHRALDH1A1GAACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105026-A1 | COMPOUND (R) -N*6*-ETHYL-6, 7-DIHYDRO-5H-INDENO (5, 6- D) THIAZOLE-2, 6-DIAMINE AND THE USE AS ANTIPSYCHOTICS | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | WO | disclosed |