Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | YWHAG | P61981 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP14 | P54578 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002225 | 0.89 | ACACB (0.44) | BRD4HRH3MAOAMAOBACACB | |
| SCHEMBL7984662 | 0.78 | RXRB (0.46) | ALDH1A1 | |
| SCHEMBL4811875 | 0.77 | PBRM1 (0.41) | BRD4PBRM1HRH3IL4I1MAOA | |
| SCHEMBL8688671 | 0.77 | PBRM1 (0.50) | BRD4PBRM1HRH3IL4I1MAOA | |
| SCHEMBL4812956 | 0.77 | PBRM1 (0.55) | BRD4PBRM1HRH3IL4I1MAOA | |
| SCHEMBL1477730 | 0.76 | PBRM1 (0.50) | BRD4PBRM1IL4I1ALDH1A1 | |
| SCHEMBL3839761 | 0.74 | PBRM1 (0.47) | BRD4PBRM1HRH3IL4I1MAOA | |
| SCHEMBL23589273 | 0.74 | ALDH1A1 (0.48) | BRD4PBRM1IL4I1MAOAMAOB | |
| SCHEMBL29203885 | 0.74 | TNKS2 (0.40) | TNKS2YWHAGAPPCYP3A4ALDH1A1 | |
| SCHEMBL12379473 | 0.74 | TNKS2 (0.43) | TNKS2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |