Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | POLB | P06746 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509276 | 0.99 | MEN1 (0.44) | MEN1KMT2ATSHRNPSR1MAPT | |
| SCHEMBL7999481 | 0.99 | KMT2A (0.44) | MEN1KMT2ATSHRNPSR1MAPT | |
| SCHEMBL7999471 | 0.93 | MEN1 (0.43) | MEN1KMT2ATSHRNPSR1MAPT | |
| SCHEMBL5507836 | 0.89 | MEN1 (0.45) | MEN1KMT2ATSHRNPSR1MAPT | |
| SCHEMBL5507853 | 0.88 | KMT2A (0.45) | MEN1KMT2ATSHRNPSR1MAPT | |
| SCHEMBL5505065 | 0.85 | POLB (0.47) | TSHRMAPTPOLBTDP1HTT | |
| SCHEMBL5507843 | 0.82 | MEN1 (0.44) | MEN1KMT2ATSHRNPSR1MAPT | |
| SCHEMBL5510426 | 0.82 | CA5A (0.45) | MAPTPOLBTDP1HTTPKM | |
| SCHEMBL5502024 | 0.81 | CA5A (0.50) | MAPTPOLBTDP1HTTPKM | |
| SCHEMBL5502011 | 0.81 | CA5A (0.50) | MAPTPOLBTDP1HTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |