Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12649761 | 0.89 | GRM5 (0.33) | GRM5 | |
| SCHEMBL8002607 | 0.89 | RORC (0.36) | RORC | |
| SCHEMBL8247691 | 0.87 | RORC (0.36) | RORCGRM5 | |
| SCHEMBL12649654 | 0.87 | GRM5 (0.36) | GRM5 | |
| SCHEMBL12947092 | 0.84 | BACE1 (0.39) | GRM5 | |
| SCHEMBL12916796 | 0.84 | BACE1 (0.39) | GRM5 | |
| SCHEMBL12649758 | 0.80 | SCN9A (0.34) | — | |
| SCHEMBL12649715 | 0.80 | — | — | |
| SCHEMBL12649778 | 0.79 | — | — | |
| SCHEMBL12649759 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288613-B1 | PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2009131975-A1 | PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE | SCHERING CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |