Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glyphosate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 7/20 | 0.35 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.33 |
| ▸ | ENO1 | P06733 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | GGH | Q92820 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.30 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.30 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyphosate SCHEMBL18578 | 0.98 | LMNA (0.42) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL118894 | 0.98 | LMNA (0.42) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL118893 | 0.98 | LMNA (0.42) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL3294890 | 0.95 | LMNA (0.40) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL1964442 | 0.95 | LMNA (0.43) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL214438 | 0.95 | LMNA (0.43) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL30579951 | 0.95 | LMNA (0.43) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL16440 | 0.95 | LMNA (0.43) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL29694166 | 0.95 | LMNA (0.43) | LMNAMEN1HPGDTSHRBLM | |
| Glyphosate SCHEMBL30579950 | 0.95 | LMNA (0.43) | LMNAMEN1HPGDTSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051533-A | SOLIDS; MIXTURE OF HERBICIDE, SURFACTANT AND SILICONE | MONSANTO COMPANY (US) | 2000-04-18 | — | — | US | disclosed |
| WO-1997002742-A1 | IMPROVED FORMULATIONS HAVING ENHANCED WATER DISSOLUTION | MONSANTO COMPANY (US) | 1997-01-30 | — | — | WO | disclosed |
| EP-0394211-B1 | IMPROVED FORMULATIONS HAVING ENHANCED WATER DISSOLUTION | MONSANTO COMPANY (US) | 1993-06-09 | — | — | EP | disclosed |
| EP-0394211-A1 | Improved formulations having enhanced water dissolution | MONSANTO COMPANY (US) | 1990-10-24 | — | — | EP | disclosed |