Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5102055 | 0.89 | OPRL1 (0.65) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL7995855 | 0.89 | OPRL1 (0.65) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL5102059 | 0.89 | OPRL1 (0.65) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL5098400 | 0.89 | OPRL1 (0.65) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL5108236 | 0.88 | OPRL1 (0.66) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| Hydrochloric Acid SCHEMBL7982541 | 0.87 | OPRL1 (0.65) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL7754142 | 0.86 | OPRL1 (0.74) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL7992800 | 0.84 | OPRL1 (0.78) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL7754117 | 0.84 | OPRL1 (0.81) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL7992870 | 0.83 | OPRL1 (0.70) | OPRL1OPRM1OPRK1OPRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | disclosed |